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Article

Complete genomic sequence of the human <i>ABCA1</i> gene: Analysis of the human and mouse ATP-binding cassette A promoter

5 Jul 2000

Abstract excerpt

The ABCA1 gene, a member of the ATP-binding cassette A (ABCA1) transporter superfamily, encodes a membrane protein that facilitates the cellular efflux of cholesterol and phospholipids. Mutations in ABCA1 lead to familial high density lipoprotein deficiency and Tangier disease. We report the complete human ABCA1 gene sequence, including 1,453 bp of the promoter, 146,581 bp of introns and exons, and 1 kb of the 3'...

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PMID: 10884428
DOI: 10.1073/pnas.97.14.7987

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