Article
Hippocampal granule neuron production and population size are regulated by levels of bFGF.
The European journal of neuroscience - 1 Jan 2002
Cheng Yinghong, Black Ira B, DiCicco-Bloom Emanuel
Abstract excerpt
Numerous studies of the proliferative effects of basic fibroblast growth factor (bFGF) in culture, including neonatal and adult hippocampal precursors, suggest that the factor plays a ubiquitous and life-long role in neurogenesis. In contrast, in vivo, bFGF is devoid of effects on neurons in mature hippocampus, raising the possibility that bFGF exhibits developmental stage-specific activity in the complex animal...
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