Immunoglobulin gene rearrangement analysis in composite hodgkin disease and large B-cell lymphoma: evidence for receptor revision of immunoglobulin heavy chain variable region genes in Hodgkin-Reed-Sternberg cells?

doi:10.1097/00019606-200203000-00002

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Article

Immunoglobulin gene rearrangement analysis in composite hodgkin disease and large B-cell lymphoma: evidence for receptor revision of immunoglobulin heavy chain variable region genes in Hodgkin-Reed-Sternberg cells?

Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 2002

Bellan Cristiana, Lazzi Stefano, Zazzi Maurizio, Lalinga Anna Vittoria, Palummo Nazareno, Galieni Piero, Marafioti Teresa, Tonini Tiziana, Cinti Caterina, Leoncini Lorenzo, Pileri Stefano A, Tosi Piero

Abstract excerpt

Immunoglobulin heavy chain gene (IgH) rearrangement was studied in a patient showing the occurrence of classical Hodgkin disease and large B-cell lymphoma (LBCL) in the same lymph node. The VHDHJH region was amplified by polymerase chain reaction, the template being the DNA extracted from single Hodgkin and Reed-Sternberg and LBCL cells, microdissected on hematoxylin-eosin-stained sections by laser capture. A...

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PMID: 11854595
DOI: 10.1097/00019606-200203000-00002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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