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Article

Dynamin and clathrin are required for the biogenesis of a distinct class of secretory vesicles in yeast.

The EMBO journal - 15 Feb 2002

Gurunathan Sangiliyandi, David Doris, Gerst Jeffrey E

Abstract excerpt

Yeast produce two classes of secretory vesicles (SVs) that differ in both density and cargo protein content. In late-acting secretory mutants (e.g. snc1(ala43) and sec6-4), both low- (LDSV) and high-density (HDSV) classes of vesicles accumulate at restrictive temperatures. Here, we have found that disruptions in the genes encoding a dynamin-related protein (VPS1) or clathrin heavy chain (CHC1) abolish HDSV...

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Identifiers

PMID: 11847108
DOI: 10.1093/emboj/21.4.602
PMCID: PMC125853

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Source receipt: pubmed, retrieved 7 Sept 2026.

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