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In Vitro Serial Passage of <i>Staphylococcus aureus</i> : Changes in Physiology, Virulence Factor Production, and <i>agr</i> Nucleotide Sequence

1 Mar 2002

Abstract excerpt

Recently, we observed that Staphylococcus aureus strains newly isolated from patients had twofold-higher aconitase activity than a strain passaged extensively in vitro, leading us to hypothesize that aconitase specific activity decreases over time during in vitro passage. To test this hypothesis, a strain recovered from a patient with toxic shock syndrome was serially passaged for 6 weeks, and the aconitase...

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PMID: 11844774
DOI: 10.1128/jb.184.5.1430-1437.2002

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