Article
Haemoglobin Pierre-Benite--a high affinity variant associated with relative polycythaemia.
Clinical and laboratory haematology - 1 Dec 2001
Beard M E, Potter H C, Spearing R L, Brennan S O
Abstract excerpt
This is the second reported example of Hb Pierre--Benite (beta90 Glu-->Asp). This mutation is associated with increased oxygen affinity and polycythaemia. No instability was found and there was no charge shift detected by cellulose acetate electrophoresis at pH 8.3. The mutation was however, clearly indicated by electrospray ionization mass spectrometry (ESI MS), which showed an abnormal beta chain with a 14 Da...
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