Article
Promoter region polymorphism of the CD14 gene (C-159T) is not associated with psoriasis vulgaris.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Feb 2002
Karhukorpi J, Ikäheimo I, Karvonen J, Karttunen R
Abstract excerpt
Keratinocytes of psoriatic skin show aberrant expression of membrane-bound CD14 (mCD14). In addition, soluble CD14 (sCD14) is elevated in the sera of psoriatic patients. The mechanisms leading to increased CD14 expression and secretion in psoriasis are poorly understood. A bi-allelic polymorphism in the promoter region of the CD14 gene controls CD14 expression on monocytes and sCD14 levels in the sera of healthy...
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