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Article

c-Myc initiates illegitimate replication of the ribonucleotide reductase R2 gene.

Oncogene - 31 Jan 2002

Kuschak T I, Kuschak B C, Taylor C L, Wright J A, Wiener F, Mai S

Abstract excerpt

The mechanisms through which the oncoprotein c-Myc initiates locus-specific gene amplification are not understood. When analysing the initiation mechanism of c-Myc-dependent amplification of the mouse ribonucleotide reductase R2 (R2) gene, we observe c-Myc-dependent initiation of illegitimate DNA replication of the R2 gene. We demonstrate multiple simultaneous c-Myc-induced R2 replication forks, whereas R2...

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Identifiers

PMID: 11840336
DOI: 10.1038/sj.onc.1205145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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