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Article

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion.

Aging - 1 Dec 2012

Mannava Sudha, Moparthy Kalyana C, Wheeler Linda J, Leonova Katerina I, Wawrzyniak Joseph A, Bianchi-Smiraglia Anna, Berman Albert E, Flanagan Sheryl, Shewach Donna S, Zeitouni Nathalie C, Gudkov Andrei V, Mathews Christopher K, Nikiforov Mikhail A

Abstract excerpt

The down-regulation of dominant oncogenes, including C-MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC-depleted melanoma cells undergo extensive DNA damage that is caused by the underexpression of thymidylate synthase (TS) and ribonucleotide reductase (RR) and subsequent depletion of deoxyribonucleoside...

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Source

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Identifiers

PMID: 23249808
DOI: 10.18632/aging.100512
PMCID: PMC3615158

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion.PMID 23249808Read ↗

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