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Article

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion.

Aging - 1 Dec 2012

Mannava Sudha, Moparthy Kalyana C, Wheeler Linda J, Leonova Katerina I, Wawrzyniak Joseph A, Bianchi-Smiraglia Anna, Berman Albert E, Flanagan Sheryl, Shewach Donna S, Zeitouni Nathalie C, Gudkov Andrei V, Mathews Christopher K, Nikiforov Mikhail A

Abstract excerpt

The down-regulation of dominant oncogenes, including C-MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC-depleted melanoma cells undergo extensive DNA damage that is caused by the underex...

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Source

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Identifiers

PMID: 23249808
DOI: 10.18632/aging.100512
PMCID: PMC3615158

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23249808-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion.PMID 23249808Read ↗

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