Article
Action range of BMP is defined by its N-terminal basic amino acid core.
Current biology : CB - 5 Feb 2002
Ohkawara Bisei, Iemura Shun-ichiro, ten Dijke Peter, Ueno Naoto
Abstract excerpt
During early development, cells receive positional information from neighboring cells to form tissue patterns in initially uniform germ layers. Ligands of the transforming growth factor (TGF-beta) superfamily are known to participate in this pattern formation. In particular, activin has been shown to act as a long-range dorsalizing signal to establish a concentration gradient in Xenopus. In contrast, BMP-2 and...
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