Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Formation of a fairly stable diazoate intermediate of 5-methyl-2'-deoxycytidine by HNO2 and NO, and its implication to a novel mutation mechanism in CpG site.

Bioorganic & medicinal chemistry - 1 Apr 2002

Suzuki Toshinori, Yamada Masaki, Nakamura Takanori, Ide Hiroshi, Kanaori Kenji, Tajima Kunihiko, Morii Takashi, Makino Keisuke

Abstract excerpt

The intermediate produced from 5-methyl-2'-deoxycytidine ((5me)dCyd) by HNO2 and NO treatments was isolated and characterized. When 10mM (5me)dCyd was incubated with 100mM NaNO2 at pH 3.7 and 37 degrees C, a previously unidentified product was formed. The product was identified as a diazoate derivative of (5me)dCyd, 1-(beta-D-2'-deoxyribofuranosyl)-5-methyl-2-oxopyrimidine-4-diazoate ((5me)dCyd-diazoate), on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azo Compounds
Share to Deoxycytidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deoxyguanosine

Share to Dinucleoside Phosphates

Share to Drug Stability

Share to Kinetics

Share to Molecular Structure

Share to Nitric Oxide

Source

Identifiers

PMID: 11836116
DOI: 10.1016/s0968-0896(01)00365-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Formation of a fairly stable diazoate intermediate of 5-methyl-2'-deoxycytidine by HNO2 and NO, and its implication to a novel mutation mechanism in CpG site.PMID 11836116Read ↗

Oxidation reactions of cytosine DNA components by hydroxyl radical and one-electron oxidants in aerated aqueous solutions.Semantic proximity Read ↗

Relatively Small Increases in the Steady-State Levels of Nucleobase Deamination Products in DNA from Human TK6 Cells Exposed to Toxic Levels of Nitric OxideSemantic proximity Read ↗

Miscoding properties of 2'-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases.Semantic proximity Read ↗

Translesional synthesis on a DNA template containing N2-methyl-2'-deoxyguanosine catalyzed by the Klenow fragment of Escherichia coli DNA polymerase I.Semantic proximity Read ↗

Design of highly efficient and selective transfer reaction of nitrosyl group to dc and d(M)C resulting in specific deamination.Semantic proximity Read ↗

Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates.Semantic proximity Read ↗

Excision by the human methylpurine DNA N-glycosylase of cyanuric acid, a stable and mutagenic oxidation product of 8-oxo-7,8-dihydroguanine.Semantic proximity Read ↗

Synthesis of 3,N4-etheno, 3,N4-ethano, and 3-(2-hydroxyethyl) derivatives of 2'-deoxycytidine and their incorporation into oligomeric DNA.Semantic proximity Read ↗

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its ProgenitorsSemantic proximity Read ↗

Potassium diazoacetate-induced p53 mutations in vitro in relation to formation of O6-carboxymethyl- and O6-methyl-2'-deoxyguanosine DNA adducts: relevance for gastrointestinal cancer.Semantic proximity Read ↗

Base modifications in plasmid DNA caused by potassium permanganate.Semantic proximity Read ↗

Mutagenic product formation due to reaction of guanine radical cation with nitrogen dioxide.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.