Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protease inhibitors effectively block cell-to-cell spread of HIV-1 between T cells

1 Dec 2013

Abstract excerpt

BACKGROUND: The Human Immunodeficiency Virus type-1 (HIV-1) spreads by cell-free diffusion and by direct cell-to-cell transfer, the latter being a significantly more efficient mode of transmission. Recently it has been suggested that cell-to-cell spread may permit ongoing virus replication in the presence of antiretroviral therapy (ART) based on studies performed using Reverse Transcriptase Inhibitors (RTIs)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV/AIDS Research and Interventions
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24364896
DOI: 10.1186/1742-4690-10-161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protease inhibitors effectively block cell-to-cell spread of HIV-1 between T cellsPMID 24364896Read ↗

Antiretroviral Agents Effectively Block HIV Replication after Cell-to-Cell TransferSemantic proximity Read ↗

Cell-to-cell HIV-1 spread and its implications for immune evasionSemantic proximity Read ↗

Cell-to-cell infection by HIV contributes over half of virus infectionSemantic proximity Read ↗

Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistanceSemantic proximity Read ↗

Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populationsSemantic proximity Read ↗

High multiplicity HIV-1 cell-to-cell transmission from macrophages to CD4+ T cells limits antiretroviral efficacySemantic proximity Read ↗

Cell-to-cell transfer of HIV infection: implications for HIV viral persistenceSemantic proximity Read ↗

Resistance to protease inhibitors in a model of HIV-1 infection with impulsive drug effects.Semantic proximity Read ↗

Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapySemantic proximity Read ↗

Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.Semantic proximity Read ↗

Partial Inhibition of Human Immunodeficiency Virus Replication by Type I Interferons: Impact of Cell-to-Cell Viral TransferSemantic proximity Read ↗

Identification of an env-defective HIV-1 mutant capable of spontaneous reversion to a wild-type phenotype in certain T-cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.