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Article

Antiretroviral Agents Effectively Block HIV Replication after Cell-to-Cell Transfer

14 Jun 2012

Abstract excerpt

Cell-to-cell transmission of HIV has been proposed as a mechanism contributing to virus escape to the action of antiretrovirals and a mode of HIV persistence during antiretroviral therapy. Here, cocultures of infected HIV-1 cells with primary CD4(+) T cells or lymphoid cells were used to evaluate virus transmission and the effect of known antiretrovirals. Transfer of HIV antigen from infected to uninfected cells...

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PMID: 22696642
DOI: 10.1128/jvi.01044-12

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