Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WTC deafness Kyoto (dfk): a rat model for extensive investigations of Kcnq1 functions.

Physiological genomics - 14 Feb 2006

Gohma Hiroshi, Kuramoto Takashi, Kuwamura Mitsuru, Okajima Ryoko, Tanimoto Noriaki, Yamasaki Ken-ichi, Nakanishi Satoshi, Kitada Kazuhiro, Makiyama Takeru, Akao Masaharu, Kita Toru, Sasa Masashi, Serikawa Tadao

Abstract excerpt

KCNQ1 forms K+ channels by assembly with regulatory subunit KCNE proteins and plays a key role in the K+ homeostasis in a variety of tissues. In the heart, KCNQ1 is coassembled with KCNE1 to produce a cardiac delayed rectifier K+ current. In the inner ear, the KCNQ1/KCNE1 complex maintains the high concentration of K+ in the endolymph. In the stomach, KCNQ1 is coassembled with KCNE2 to form the K+ exflux channel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deafness
Share to Ear, Inner

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrocardiography

Share to Gastric Acid

Share to Gastric Mucosa

Share to KCNQ1 Potassium Channel

Share to Models, Animal

Share to Rats, Inbred Strains

Source

Identifiers

PMID: 16368876
DOI: 10.1152/physiolgenomics.00221.2005

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WTC deafness Kyoto (dfk): a rat model for extensive investigations of Kcnq1 functions.PMID 16368876Read ↗

KCNQ potassium channels: physiology, pathophysiology, and pharmacology.Semantic proximity Read ↗

KCNQ1 K+ channel-mediated cardiac channelopathies.Semantic proximity Read ↗

Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange-Nielsen Syndrome.Semantic proximity Read ↗

Neuronal KCNQ potassium channels: physiology and role in disease.Semantic proximity Read ↗

Pathophysiology of KCNQ channels: neonatal epilepsy and progressive deafness.Semantic proximity Read ↗

A humanized murine model, demonstrating dominant progressive hearing loss caused by a novel KCNQ4 mutation (p.G228D) from a large Chinese family.Semantic proximity Read ↗

The multifaceted phenotype of the knockout mouse for the KCNE1 potassium channel gene.Semantic proximity Read ↗

KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.Semantic proximity Read ↗

Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice.Semantic proximity Read ↗

[EAST/SeSAME syndrome and functional expression of inward rectifier potassium channel Kir4.1 in the inner ear].Semantic proximity Read ↗

Connexin Mutations and Hereditary Diseases.Semantic proximity Read ↗

Gap junctions and cochlear homeostasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.