Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002

Degtyareva Natasha P, Greenwell Patricia, Hofmann E Randal, Hengartner Michael O, Zhang Lijia, Culotti Joseph G, Petes Thomas D

Abstract excerpt

Mismatch repair genes are important in maintaining the fidelity of DNA replication. To determine the function of the Caenorhabditis elegans homologue of the MSH2 mismatch repair gene (msh-2), we isolated a strain of C. elegans with an insertion of the transposable element Tc1 within msh-2. Early-passage msh-2 mutants were similar to wild-type worms with regard to lifespan and meiotic chromosome segregation but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pair Mismatch
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to DNA Transposable Elements

Share to Dose-Response Relationship, Radiation

Share to Meiosis

Share to MutS DNA Mismatch-Binding Protein

Share to MutS Homolog 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 11830642
DOI: 10.1073/pnas.032671599
PMCID: PMC122335

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity.PMID 11830642Read ↗

Frequent Germline Mutations and Somatic Repeat Instability in DNA Mismatch-Repair-Deficient Caenorhabditis elegansSemantic proximity Read ↗

Mutation rate and spectrum in obligately outcrossing Caenorhabditis elegans mutation accumulation lines subjected to RNAi-induced knockdown of the mismatch repair gene msh-2.Semantic proximity Read ↗

Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans.Semantic proximity Read ↗

The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation.Semantic proximity Read ↗

Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers.Semantic proximity Read ↗

MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans.Semantic proximity Read ↗

Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants.Semantic proximity Read ↗

The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline.Semantic proximity Read ↗

Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability.Semantic proximity Read ↗

Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans.Semantic proximity Read ↗

C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein.Semantic proximity Read ↗

Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.