Article
Complex HBV populations with mutations in core promoter, C gene, and pre-S region are associated with development of cirrhosis in long-term renal transplant recipients.
Hepatology (Baltimore, Md.) - 1 Feb 2002
Preikschat Petra, Günther Stephan, Reinhold Simone, Will Hans, Budde Klemenz, Neumayer Hans H, Krüger Detlev H, Meisel Helga
Abstract excerpt
Long-term immunosuppressed renal transplant recipients with chronic hepatitis B virus (HBV) infection often develop liver cirrhosis (LC) and end-stage liver disease (ESLD). This study investigated accumulation and persistence of specific HBV mutants in relation to the clinical course in these patients (n = 38; mean follow-up, 3.5 years). HBV was analyzed longitudinally via length polymorphism of polymerase chain...
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