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Article

Evidence for the involvement of cathepsin B in skeletal myoblast differentiation.

Journal of cellular biochemistry - 1 Jan 2002

Jane Derek T, DaSilva Luis, Koblinski Jennifer, Horwitz Marshall, Sloane Bonnie F, Dufresne Michael J

Abstract excerpt

Our previous studies suggest that the cysteine protease cathepsin B (catB) is involved in skeletal myoblast differentiation (myogenesis). To test this hypothesis, we examined the effect of trapping one of the two catB alleles on the ability of C2C12 cells to differentiate. During differentiation, catB gene-trapped C2C12 mouse myoblasts (RT-27) demonstrated a similar pattern of intracellular catB activity and...

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PMID: 11813257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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