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Article

La autoantigen enhances translation of BiP mRNA

15 Dec 2001

Abstract excerpt

Translational initiation of the human BiP mRNA is directed by an internal ribosomal entry site (IRES) located in the 5'-untranslated region (5'-UTR). In order to understand the mechanism of the IRES-dependent translation of BiP mRNA, cellular proteins interacting with the BiP IRES were investigated. La autoantigen, which augments the translation of polioviral mRNA and hepatitis C viral mRNA, bound specifically to...

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PMID: 11812831
DOI: 10.1093/nar/29.24.5009

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La autoantigen enhances translation of BiP mRNAPMID 11812831Read ↗

La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitro.Semantic proximity Read ↗

Location of the internal ribosome entry site in the 5' non-coding region of the immunoglobulin heavy-chain binding protein (BiP) mRNA: evidence for specific RNA-protein interactionsSemantic proximity Read ↗

Distinct mRNAs That Encode La Autoantigen Are Differentially Expressed and Contain Internal Ribosome Entry SitesSemantic proximity Read ↗

La protein is required for efficient translation driven by encephalomyocarditis virus internal ribosomal entry siteSemantic proximity Read ↗

A Xenopus laevis homologue of the La autoantigen binds the pyrimidine tract of the 5' UTR of ribosomal protein mRNAs in vitro: implication of a protein factor in complex formation.Semantic proximity Read ↗

An apical GAGA loop within 5' UTR of the coxsackievirus B3 RNA maintains structural organization of the IRES element required for efficient ribosome entry.Semantic proximity Read ↗

Hepatitis C Virus Internal Ribosome Entry Site-mediated Translation Is Stimulated by Specific Interaction of Independent Regions of Human La AutoantigenSemantic proximity Read ↗

Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translationSemantic proximity Read ↗

Inhibition of host cell translation elongation by Legionella pneumophila blocks the host cell unfolded protein responseSemantic proximity Read ↗

Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity.Semantic proximity Read ↗

La protein binding at the GCAC site near the initiator AUG facilitates the ribosomal assembly on the hepatitis C virus RNA to influence internal ribosome entry site-mediated translation.Semantic proximity Read ↗

Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap.Semantic proximity Read ↗

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