Article
Down-regulation of Mcl-1 by inhibition of the PI3-K/Akt pathway is required for cell shrinkage-dependent cell death.
Biochemical and biophysical research communications - 1 Feb 2002
Araki Takashi, Hayashi Matsuhiko, Watanabe Naohide, Kanuka Hirotaka, Yoshino Jun, Miura Masayuki, Saruta Takao
Abstract excerpt
The anti-apoptotic effect of a chloride-bicarbonate exchange blocker has been previously examined in endothelial cells and cardiomyocytes. However, the anti-apoptotic effects of this blocker on epithelial cells and the mechanism of the anti-apoptotic effect remain unknown. We examined the anti-apoptotic effects of a chloride-bicarbonate exchange blocker in a renal epithelial cell line (MDCK cells). Changes in the...
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