Article
Subcellular localization of the homocitrate synthase in Penicillium chrysogenum.
Molecular genetics and genomics : MGG - 1 Jan 2002
Bañuelos O, Casqueiro J, Steidl S, Gutiérrez S, Brakhage A, Martín J F
Abstract excerpt
There are conflicting reports regarding the cellular localization in Saccharomyces cerevisiae and filamentous fungi of homocitrate synthase, the first enzyme in the lysine biosynthetic pathway. The homocitrate synthase (HS) gene (lys1) of Penicillium chrysogenum was disrupted in three transformants (HS(-)) of the Wis 54-1255 pyrG strain. The three mutants named HS1(-), HS2(-) and HS3(-) all lacked homocitrate...
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