Article
Cytosolic hydroxymethyldihydropterin pyrophosphokinase/dihydropteroate synthase from Arabidopsis thaliana: a specific role in early development and stress response.
The Journal of biological chemistry - 6 Apr 2007
Storozhenko Sergei, Navarrete Oscar, Ravanel Stéphane, De Brouwer Veerle, Chaerle Peter, Zhang Guo-Fang, Bastien Olivier, Lambert Willy, Rébeillé Fabrice, Van Der Straeten Dominique
Abstract excerpt
In plants, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase (mitHPPK/DHPS) is a bifunctional mitochondrial enzyme, which catalyzes the first two consecutive steps of tetrahydrofolate biosynthesis. Mining the Arabidopsis genome data base has revealed a second gene encoding a protein that lacks a potential transit peptide, suggesting a cytosolic localization of the isoenzyme...
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