Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p.

European journal of biochemistry - 1 Apr 1999

Feller A, Ramos F, Piérard A, Dubois E

Abstract excerpt

Expression of the structural genes for lysine biosynthesis responds to an induction mechanism mediated by the transcriptional activator Lys14p in the presence of alpha-aminoadipate semialdehyde (alphaAASA), an intermediate of the pathway acting as a coinducer. This activation is reduced by the presence of lysine in the growth medium, leading to apparent repression. In this report we demonstrate that Saccharomyces...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Feedback
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Genes, Fungal

Share to Isoenzymes

Share to Lysine

Share to Oxo-Acid-Lyases

Share to Subcellular Fractions

Source

Identifiers

PMID: 10103047
DOI: 10.1046/j.1432-1327.1999.00262.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p.PMID 10103047Read ↗

Lysine-overproducing mutants of Saccharomyces cerevisiae baker's yeast isolated in continuous culture.Semantic proximity Read ↗

Loss of compartmentalization causes misregulation of lysine biosynthesis in peroxisome-deficient yeast cells.Semantic proximity Read ↗

Structural basis for L-lysine feedback inhibition of homocitrate synthase.Semantic proximity Read ↗

Substrate activation of brewers' yeast pyruvate decarboxylase is abolished by mutation of cysteine 221 to serine.Semantic proximity Read ↗

Aspartokinase III repression and lysine analogs utilization for protein synthesis.Semantic proximity Read ↗

The Aspergillus nidulans lysF gene encodes homoaconitase, an enzyme involved in the fungus-specific lysine biosynthesis pathway.Semantic proximity Read ↗

The Saccharomyces cerevisiae LYS7 gene is involved in oxidative stress protection.Semantic proximity Read ↗

Lysine is synthesized through the alpha-aminoadipate pathway in Thermus thermophilus.Semantic proximity Read ↗

[Lysine overproduction mutations in the yeast Saccharomyces cerevisiae and its transfection into industrial Yeast strains ].Semantic proximity Read ↗

Three target genes for the transcriptional activator Cat8p of Kluyveromyces lactis: acetyl coenzyme A synthetase genes KlACS1 and KlACS2 and lactate permease gene KlJEN1.Semantic proximity Read ↗

Analysis and manipulation of aspartate pathway genes for L-lysine overproduction from methanol by Bacillus methanolicus.Semantic proximity Read ↗

Site-directed mutational analysis of the novel catalytic domains of alpha-aminoadipate reductase (Lys2p) from Candida albicans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.