Article
Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal.
Mutation research - 18 Jun 2009
Maddukuri Leena, Speina Elzbieta, Christiansen Mette, Dudzińska Dominika, Zaim Jolanta, Obtułowicz Tomasz, Kabaczyk Sylwia, Komisarski Marek, Bukowy Zuzanna, Szczegielniak Jadwiga, Wójcik Andrzej, Kuśmierek Jaroslaw T, Stevnsner Tinna, Bohr Vilhelm A, Tudek Barbara
Abstract excerpt
Cockayne syndrome complementation group B (CSB) protein is engaged in transcription-coupled repair (TCR) of UV induced DNA damage and its deficiency leads to progressive multisystem degeneration and premature aging. Here, we show that human CSB-deficient cells are hypersensitive to physiological concentrations (1-10 microM) of a lipid peroxidation product, trans-4-hydroxy-2-nonenal (HNE), and in response to HNE...
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