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Article

FADD: A link between TNF family receptors and caspases in Parkinson’s disease

22 Jan 2002

Abstract excerpt

Fas-associating protein with a death domain (FADD) is a proximal adaptor protein of the tumor necrosis factor (TNF) receptor family death pathway. This human postmortem study showed a significant decrease in the percentage of FADD-immunoreactive dopaminergic (DA) neurons in the substantia nigra pars compacta of patients with PD compared with controls (-24.8%). This decrease correlated with the known selective...

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PMID: 11805265
DOI: 10.1212/wnl.58.2.308

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