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Article

Low serum 25-hydroxyvitamin D levels may increase the detrimental effect of VDR variants on the risk of essential hypertension.

European journal of clinical nutrition - 1 Jul 2020

Shen Fang, Guo Changman, Wang Yan, Yu Fei, Zhang Dongdong, Liu Xue, Ba Yue, Wang Chongjian, Li Wenjie, Li Xing

Abstract excerpt

BACKGROUND/OBJECTIVES: The present cross-sectional study evaluated the association of vitamin D receptor (VDR) variants with serum 25(OH)D3 levels and their interaction on essential hypertension (EH) risk. SUBJECTS/METHODS: 1539 patients were eligible in the study population. Two loci in VDR gene (rs2239179, rs2189480) were genotyped by TaqMan probe assays. Logistic regression, Kruskal-Wallis rank test and...

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PMID: 31827258
DOI: 10.1038/s41430-019-0543-5

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