Article
Modeling age x major gene interaction by a variance component approach.
Genetic epidemiology - 1 Jan 2001
Shete S S, Chen J, Zhou X, Amos C I
Abstract excerpt
The variance component method has become popular for linkage analysis due to its computational simplicity and generally high power. In this paper we model phenotypic variability of an individual as a mixed effects model in which both the major gene as well as the polygene effects interact with age. We applied the proposed model to the simulated data of Genetic Analysis Workshop 12. We considered the quantitative...
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