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Article

Identification of a common sphingolipid-binding domain in Alzheimer, prion, and HIV-1 proteins.

The Journal of biological chemistry - 29 Mar 2002

Mahfoud Radhia, Garmy Nicolas, Maresca Marc, Yahi Nouara, Puigserver Antoine, Fantini Jacques

Abstract excerpt

The V3 loop of the human immunodeficiency virus (HIV)-1 surface envelope glycoprotein gp120 is a sphingolipid-binding domain mediating the attachment of HIV-1 to plasma membrane microdomains (rafts). Sphingolipid-induced conformational changes in gp120 are required for HIV-1 fusion. Galactosylceramide and sphingomyelin have been detected in highly purified preparations of prion rods, suggesting that the prion...

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Identifiers

PMID: 11792705
DOI: 10.1074/jbc.M111679200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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