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Article

Rapid structural fluctuations of the free HIV protease flaps in solution: relationship to crystal structures and comparison with predictions of dynamics calculations.

Protein science : a publication of the Protein Society - 1 Feb 2002

Freedberg Darón I, Ishima Rieko, Jacob Jaison, Wang Yun-Xing, Kustanovich Irina, Louis John M, Torchia Dennis A

Abstract excerpt

Crystal structures have shown that the HIV-1 protease flaps, domains that control access to the active site, are closed when the active site is occupied by a ligand. Although flap structures ranging from closed to semi-open are observed in the free protease, crystal structures reveal that even the semi-open flaps block access to the active site, indicating that the flaps are mobile in solution. The goals of this...

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Identifiers

PMID: 11790832
DOI: 10.1110/ps.33202
PMCID: PMC2373438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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