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Article

Flap-site Fragment Restores Back Wild-type Behaviour in Resistant Form of HIV Protease.

Molecular informatics - 1 Dec 2018

Luchi Adriano, Angelina Emilio, Bogado Lucrecia, Forli Stefano, Olson Arthur, Peruchena Nélida

Abstract excerpt

HIV-1 protease (HIV-PR) performs a vital step in the virus life cycle which makes it an excellent target for drug therapy. However, due to the error-prone of HIV reverse transcriptase, mutations in HIV-PR often occur, inducing drug-resistance to inhibitors. Some HIV-PR mutations can make the flaps of the enzyme more flexible thus increasing the flaps opening rate and inhibitor releasing. It has been shown that by...

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Source

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Identifiers

PMID: 30051611
DOI: 10.1002/minf.201800053
PMCID: PMC6501176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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