Article
Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function.
Structure (London, England : 1993) - 15 Sept 1999
Ishima R, Freedberg D I, Wang Y X, Louis J M, Torchia D A
Abstract excerpt
BACKGROUND: (1)H and (15)N transverse relaxation measurements on perdeuterated proteins are ideally suited for detecting backbone conformational fluctuations on the millisecond-microsecond timescale. The identification of conformational exchange on this timescale by measuring the relaxation of both (1)H and (15)N holds great promise for the elucidation of functionally relevant conformational changes in proteins....
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