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Article

Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans.

The Journal of pharmacology and experimental therapeutics - 1 Dec 1997

McCarver D G, Thomasson H R, Martier S S, Sokol R J, Li T

Abstract excerpt

Considerable variation in offspring outcome is observed after intrauterine alcohol exposure. The underlying mechanism may include genetic diversity in the enzymes responsible for alcohol metabolism. Of the known genetic polymorphisms, differences at the alcohol dehydrogenase-2 locus (ADH2) are likely most critical because the resulting enzymes are >30-fold different in their kinetic constants. To test whether...

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PMID: 9399981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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