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Article

Profiles of adaptation in two similar viruses.

Genetics - 1 Dec 2001

Holder K K, Bull J J

Abstract excerpt

The related bacteriophages phiX174 and G4 were adapted to the inhibitory temperature of 44 degrees and monitored for nucleotide changes throughout the genome. Phage were evolved by serial transfer at low multiplicity of infection on rapidly dividing bacteria to select genotypes with the fastest rates of reproduction. Both phage showed overall greater fitness effects per substitution during the early stages of...

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Identifiers

PMID: 11779783
DOI: 10.1093/genetics/159.4.1393
PMCID: PMC1461900

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Source receipt: pubmed, retrieved 7 Sept 2026.

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