Article
c-myc Suppression in Burkitt's lymphoma cells.
Biochemical and biophysical research communications - 11 Jan 2002
Simonsson Tomas, Henriksson Marie
Abstract excerpt
The purpose of the study was to elucidate how DNA tetraplex (also referred to as G-quadruplex)-forming oligonucleotides mediate suppression of the human c-myc gene at the level of transcription initiation. A 22-base-long oligonucleotide, which is rich in guanines and folds into an intrastrand DNA tetraplex under physiological conditions, was administered to a Burkitt's lymphoma cell line overexpressing a (8:14)...
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