Article
Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension.
Circulation - 1 Jan 2002
Iwai Naoharu, Katsuya Tomohiro, Mannami Toshifumi, Higaki Jitsuo, Ogihara Toshio, Kokame Koichi, Ogata Jun, Baba Shunroku
Abstract excerpt
BACKGROUND: The SA gene (SAH) has been isolated by differential screening from a genetically hypertensive rat strain as a candidate gene that may contribute to hypertension. Recently, the SA protein has been reported to be highly homologous to bovine xenobiotic-metabolizing medium-chain fatty acid:CoA ligase. METHODS AND RESULTS: To clarify the pathophysiological significance of SAH, we searched for polymorphisms...
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