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Article

Optimization of the cell wall microenvironment allows increased production of recombinant Bacillus anthracis protective antigen from B. subtilis.

Applied and environmental microbiology - 1 Jan 2002

Thwaite Joanne E, Baillie Les W J, Carter Noel M, Stephenson Keith, Rees Mark, Harwood Colin R, Emmerson Peter T

Abstract excerpt

The stability of heterologous proteins secreted by gram-positive bacteria is greatly influenced by the microenvironment on the trans side of the cytoplasmic membrane, and secreted heterologous proteins are susceptible to rapid degradation by host cell proteases. In Bacillus subtilis, degradation occurs either as the proteins emerge from the presecretory translocase and prior to folding into their native...

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Identifiers

PMID: 11772631
DOI: 10.1128/AEM.68.1.227-234.2002
PMCID: PMC126578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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