Article
D-Alanine substitution of teichoic acids as a modulator of protein folding and stability at the cytoplasmic membrane/cell wall interface of Bacillus subtilis.
The Journal of biological chemistry - 1 Sept 2000
Hyyrylainen H L, Vitikainen M, Thwaite J, Wu H, Sarvas M, Harwood C R, Kontinen V P, Stephenson K
Abstract excerpt
The extracytoplasmic folding of secreted proteins in Gram-positive bacteria is influenced by the microenvironment of the compartment into which they are translocated, namely the negatively charged matrix of the cell wall polymers. In this compartment, the PrsA lipoprotein facilitates correct post-translocational folding or prevents misfolding of secreted proteins. In this study, a secretion mutant of B. subtilis...
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