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Article

The alphaA-crystallin R116C mutant has a higher affinity for forming heteroaggregates with alphaB-crystallin.

Biochemistry - 8 Jan 2002

Bera Sibes, Abraham Edathara C

Abstract excerpt

An autosomal dominant congenital cataract in humans is associated with mutation of Arg-116 to Cys in alphaA-crystallin (alphaA-R116C). The chaperone activity and biophysical properties of reconstituted alpha-crystallin from different proportions of wild-type alphaB-crystallin (alphaB-wt) and alphaA-R116C-crystallin were studied by gel permeation chromatography, SDS-polyacrylamide gel electrophoresis, and...

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PMID: 11772029
DOI: 10.1021/bi011010v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The alphaA-crystallin R116C mutant has a higher affinity for forming heteroaggregates with alphaB-crystallin.PMID 11772029Read ↗

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