Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternative metabolic pathways for energy supply and resistance to apoptosis in Fanconi anaemia.

Mutagenesis - 1 Jan 2002

Bogliolo Massimo, Borghini Silvia, Abbondandolo Angelo, Degan Paolo

Abstract excerpt

Deregulation of control of the apoptotic process in Fanconi anaemia (FA) appears to be one of the main features of this disease at the cellular level. We show here that FA cells are resistant to treatments with rhodamine-1,2,3 and doxycycline, which both interfere with mitochondrial functionality by different mechanisms. In contrast, normal lymphoblastoid cells are severely affected by these treatments, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deoxyglucose
Share to Doxycycline
Share to Fanconi Anemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group A Protein

Share to Fanconi Anemia Complementation Group Proteins

Share to Intracellular Membranes

Share to Leukemia, Myeloid

Share to Rhodamine 123

Source

Identifiers

PMID: 11752230
DOI: 10.1093/mutage/17.1.25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Alternative metabolic pathways for energy supply and resistance to apoptosis in Fanconi anaemia.PMID 11752230Read ↗

Mitochondrial respiratory chain Complex I defects in Fanconi anemia complementation group A.Semantic proximity Read ↗

Re-definition and supporting evidence toward Fanconi Anemia as a mitochondrial disease: Prospects for new design in clinical management.Semantic proximity Read ↗

Mutated FANCA Gene Role in the Modulation of Energy Metabolism and Mitochondrial Dynamics in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Concentration‐dependent metabolic effects of metformin in healthy and Fanconi anemia lymphoblast cellsSemantic proximity Read ↗

Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy.Semantic proximity Read ↗

Impaired mitochondrial Ca2+ homeostasis in respiratory chain-deficient cells but efficient compensation of energetic disadvantage by enhanced anaerobic glycolysis due to low ATP steady state levels.Semantic proximity Read ↗

Glycolytic inhibition by mutation of pyruvate kinase gene increases oxidative stress and causes apoptosis of a pyruvate kinase deficient cell line.Semantic proximity Read ↗

p53-dependent pathway of radio-induced apoptosis is altered in Fanconi anemia.Semantic proximity Read ↗

Low-concentration methylene blue maintains energy production and strongly improves survival of Leigh syndrome French Canadian skin fibroblasts.Semantic proximity Read ↗

Defective RNA ribose synthesis in fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA).Semantic proximity Read ↗

Adenosine triphosphate depletion of erythrocytes simulates the phenotype associated with pyruvate kinase deficiency and confers protection against Plasmodium falciparum in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.