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Article

Defective RNA ribose synthesis in fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA).

Blood - 15 Nov 2003

Boros László G, Steinkamp Mara P, Fleming Judith C, Lee Wai-Nang Paul, Cascante Marta, Neufeld Ellis J

Abstract excerpt

Fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA) syndrome with diabetes and deafness undergo apoptotic cell death in the absence of supplemental thiamine in their cultures. The basis of megaloblastosis in these patients has not been determined. Here we use the stable...

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Identifiers

PMID: 12893755
DOI: 10.1182/blood-2003-05-1537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12893755-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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