Article
The role of c-myc in regulating mdr1 gene expression in tumor cell line KB.
Chinese medical journal - 1 Sept 2000
He Y, Zhang J, Zhang J, Yuan Y
Abstract excerpt
OBJECTIVE: To investigate the relationship between c-myc expression and mdr1 regulation in multidrug resistance (MDR) tumor cell line KBv200. METHODS: A DNA sequence encoding the ribozyme gene was incorporated into a eukaryotic expression vector (pH beta Apr-1 neo) and transfected into the cell line KB, which is resistant to vincristine and expresses the MDR phenotype. The changes of c-myc protein, P-glycoprotein...
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