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Article

Disulfide-mediated dimerization of L1 Ig domains.

Journal of neuroscience research - 1 Nov 2001

Haspel J, Schürmann G, Jacob J, Erickson H P, Grumet M

Abstract excerpt

The neural cell adhesion molecule L1 contains immunoglobulin-like (Ig) domains in its extracellular region that mediate homophilic binding, neurite outgrowth and other activities relevant to CNS development. To correlate conformations of these domains to biological function, several L1-Fc fusion proteins whose bioactivities were previously characterized were analyzed by rotary shadowing electron microscopy. We...

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PMID: 11746352
DOI: 10.1002/jnr.1227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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