Article
Oligomerization-induced conformational change in the C-terminal region of Nel-like molecule 1 (NELL1) protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading.
The Journal of biological chemistry - 4 Apr 2014
Nakamura Yoko, Hasebe Ai, Takahashi Kaneyoshi, Iijima Masumi, Yoshimoto Nobuo, Maturana Andrés D, Ting Kang, Kuroda Shun'ichi, Niimi Tomoaki
Abstract excerpt
NELL1 is a large oligomeric secretory glycoprotein that functions as an osteoinductive factor. NELL1 contains several conserved domains, has structural similarities to thrombospondin 1, and supports osteoblastic cell adhesion through integrins. To define the structural requirements for NELL1-mediated cell adhesion, we prepared a series of recombinant NELL1 proteins (intact, deleted, and cysteine-mutant) from a...
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