Article
Cervicovaginal lamina propria lymphocytes: phenotypic characterization and their importance in cytotoxic T-lymphocyte responses to simian immunodeficiency virus SIVmac251.
Journal of virology - 1 Jan 2002
Stevceva Liljana, Kelsall Brian, Nacsa Janos, Moniuszko Marcin, Hel Zdenek, Tryniszewska Elzbieta, Franchini Genoveffa
Abstract excerpt
Most human immunodeficiency virus (HIV) type 1 infections occur by the mucosal route. Thus, it is important to assess the immune responses to HIV in the vaginal, cervical, and rectal compartments. Here we quantitated the virus-specific CD8+ T-cell response and characterized the phenotype of lymphocytes in the genital tracts of naive macaques, macaques acutely or chronically infected with simian immunodeficiency...
Topics
- Animals
- Antigens, CD
- Basement Membrane
- CD4 Antigens
- CD8 Antigens
- Cervix Uteri
- Disease Models, Animal
- E-Selectin
- Female
- Flow Cytometry
- Gene Products, gag
- HIV
- Integrin alpha Chains