Article
A tumor host range selection procedure identifies p150(sal2) as a target of polyoma virus large T antigen.
Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2001
Li D, Dower K, Ma Y, Tian Y, Benjamin T L
Abstract excerpt
Cancer cells may undergo loss or alterations in functions that certain viruses normally target to promote virus replication. Virus mutants that have lost the targeting function(s) should be able to grow in such cancer cells but not in normal cells. A "tumor host range" (t-hr) selection procedure has been devised and applied to polyoma virus based on this rationale. Studies of one t-hr mutant have led to the...
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