Article
A role for N-WASP in invasin-promoted internalisation.
FEBS letters - 30 Nov 2001
McGee K, Zettl M, Way M, Fällman M
Abstract excerpt
Phagocytosis of Yersinia pseudotuberculosis occurs through interaction of the bacterial protein invasin with beta1-integrins. Here we report that N-WASP plays a role in internalisation of an invasin-expressing, avirulent strain of Y. pseudotuberculosis. Ectopic expression of N-WASP mutants, which affect recruitment of the Arp2/3 complex to the phagosome, reduces uptake of Yersinia. In addition, expression of the...
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