Article
Drosophila-raf acts to elaborate dorsoventral pattern in the ectoderm of developing embryos.
Genetics - 1 Nov 2001
Radke K, Johnson K, Guo R, Davidson A, Ambrosio L
Abstract excerpt
In the early Drosophila embryo the activity of the EGF-receptor (Egfr) is required to instruct cells to adopt a ventral neuroectodermal fate. Using a gain-of-function mutation we showed that D-raf acts to transmit this and other late-acting embryonic Egfr signals. A novel role for D-raf was also identified in lateral cell development using partial loss-of-function D-raf mutations. Thus, we provide evidence that...
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