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Article

Single tube genotyping of sickle cell anaemia using PCR-based SNP analysis.

Nucleic acids research - 1 Dec 2001

Waterfall C M, Cobb B D

Abstract excerpt

Allele-specific amplification (ASA) is a generally applicable technique for the detection of known single nucleotide polymorphisms (SNPs), deletions, insertions and other sequence variations. Conventionally, two reactions are required to determine the zygosity of DNA in a two-allele system, along with significant upstream optimisation to define the specific test conditions. Here, we combine single tube...

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Share to Alleles
Share to Anemia, Sickle Cell
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemoglobin, Sickle

Share to Molecular Biology Techniques and Applications

Share to Polymerase Chain Reaction

Share to Polymorphism, Single Nucleotide

Share to Sensitivity and Specificity

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Identifiers

PMID: 11726702
DOI: 10.1093/nar/29.23.e119
PMCID: PMC96713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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