Article
Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.
Blood - 15 Sept 2002
Krackhardt Angela M, Witzens Mathias, Harig Sabine, Hodi F Stephen, Zauls A Jason, Chessia Morgan, Barrett Patrick, Gribben John G
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is associated with a variety of immunologic disturbances. Hypogammaglobulinemia and autoimmune phenomena are both often present in this disease. In contrast, humoral or cellular antitumor responses are rarely observed. It has been previously shown that antigens detected in patients with malignant diseases can provide information regarding intracellular molecules engaged in the...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Antigens, Neoplasm
- Autoantibodies
- Case-Control Studies
- Cloning, Molecular
- Female
- Genetic Variation
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Male
- Middle Aged
- Molecular Sequence Data
- Peptide Library