Article
The origin of stroma surrounding epithelial ovarian cancer cells.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Jan 2013
Akahane Tomoko, Hirasawa Akira, Tsuda Hiroshi, Kataoka Fumio, Nishimura Sadako, Tanaka Hideo, Tominaga Eiichiro, Nomura Hiroyuki, Chiyoda Tatsuyuki, Iguchi Yoko, Yamagami Wataru, Susumu Nobuyuki, Aoki Daisuke
Abstract excerpt
Cancer stroma is thought to play an important role in tumor behavior, including invasion or metastasis and response to therapy. Cancer stroma is generally thought either to be non-neoplastic cells, including tissue-marrow or bone-marrow-derived fibroblasts, or to originate in epithelial mesenchymal transition of cancer cells. In this study, we evaluated the status of the p53 gene in both the cancer cells and the...
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