Article
Twin concordance and sibling recurrence rates in multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 2003
Willer C J, Dyment D A, Risch N J, Sadovnick A D, Ebers G C
Abstract excerpt
Size and ascertainment constraints often limit twin studies to concordance comparisons between identical and fraternal twins. Here we report the final results of a longitudinal, population-based study of twins with multiple sclerosis (MS) in Canada. Bias was demonstrably minimized, and an estimated 75% of all Canadian MS twin pairs were ascertained, giving a sample sufficiently large (n = 370) to permit...
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